Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis

Structural simplification of an antimitotic natural product podophyllotoxin with mimetic heterocyclic scaffolds constructed using multicomponent reactions led to the identification of compounds exhibiting low nanomolar antiproliferative and apoptosis-inducing properties. The most potent compounds we...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Magedov, Igor V., Frolova, Liliya, Manpadi, Madhuri, Bhoga, Uma devi, Tang, Hong, Evdokimov, Nikolai M., George, Olivia, Georgiou, Kathy Hadje, Renner, Steffen, Getlic, Matthäus, Kinnibrugh, Tiffany L., Fernandes, Manuel A., Van slambrouck, Severine, Steelant, Wim F. A., Shuster, Charles B., Rogelj, Snezna, van Otterlo, Willem A. L., Kornienko, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205970/
https://ncbi.nlm.nih.gov/pubmed/21615090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200410r
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados