Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis

Structural simplification of an antimitotic natural product podophyllotoxin with mimetic heterocyclic scaffolds constructed using multicomponent reactions led to the identification of compounds exhibiting low nanomolar antiproliferative and apoptosis-inducing properties. The most potent compounds we...

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Hoofdauteurs: Magedov, Igor V., Frolova, Liliya, Manpadi, Madhuri, Bhoga, Uma devi, Tang, Hong, Evdokimov, Nikolai M., George, Olivia, Georgiou, Kathy Hadje, Renner, Steffen, Getlic, Matthäus, Kinnibrugh, Tiffany L., Fernandes, Manuel A., Van slambrouck, Severine, Steelant, Wim F. A., Shuster, Charles B., Rogelj, Snezna, van Otterlo, Willem A. L., Kornienko, Alexander
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205970/
https://ncbi.nlm.nih.gov/pubmed/21615090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200410r
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