Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis

Structural simplification of an antimitotic natural product podophyllotoxin with mimetic heterocyclic scaffolds constructed using multicomponent reactions led to the identification of compounds exhibiting low nanomolar antiproliferative and apoptosis-inducing properties. The most potent compounds we...

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Xehetasun bibliografikoak
Egile Nagusiak: Magedov, Igor V., Frolova, Liliya, Manpadi, Madhuri, Bhoga, Uma devi, Tang, Hong, Evdokimov, Nikolai M., George, Olivia, Georgiou, Kathy Hadje, Renner, Steffen, Getlic, Matthäus, Kinnibrugh, Tiffany L., Fernandes, Manuel A., Van slambrouck, Severine, Steelant, Wim F. A., Shuster, Charles B., Rogelj, Snezna, van Otterlo, Willem A. L., Kornienko, Alexander
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205970/
https://ncbi.nlm.nih.gov/pubmed/21615090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200410r
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