Antiproliferative and Apoptosis Inducing Properties of Pyrano[3,2-c]pyridones Accessible by a One-Step Multicomponent Synthesis

4-Arylpyrano-[3,2-c]-pyridones have been prepared by a one-step cyclocondensation of 4-hydroxy-1,6-dimethylpyridin-2(1H)-one with various substituted benzaldehydes and malononitrile. These heterocycles exhibit micromolar and submicromolar antiproliferative activity in HeLa and induce apoptosis in Ju...

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Détails bibliographiques
Auteurs principaux: Magedov, Igor V., Manpadi, Madhuri, Evdokimov, Nikolai M., Elias, Eerik M., Rozhkova, Elena, Ogasawara, Marcia A., Bettale, Jennifer D., Przheval’skii, Nikolai M., Rogelj, Snezna, Kornienko, Alexander
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383048/
https://ncbi.nlm.nih.gov/pubmed/17512729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.05.004
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