Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolones

Pyrano[3,2-c]pyridone and pyrano[3,2-c]quinolone structural motifs are commonly found in alkaloids manifesting diverse biological activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed compound libr...

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Main Authors: Magedov, Igor V., Manpadi, Madhuri, Ogasawara, Marcia A., Dhawan, Adriana S., Rogelj, Snezna, Van slambrouck, Severine, Steelant, Wim F. A., Evdokimov, Nikolai M., Uglinskii, Pavel Y., Elias, Eerik M., Knee, Erica J., Tongwa, Paul, Antipin, Mikhail Yu., Kornienko, Alexander
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125133/
https://ncbi.nlm.nih.gov/pubmed/18361483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701499n
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