Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 3. Fused Uracil-Containing Heterocycles as Novel Topoisomerase-Targeting Agents

After the initial discovery of antiproliferative and apoptosis-inducing properties of a camptothecin-inspired pentacycle based on 1H-indeno[2’,1’:5,6]dihydropyrido[2,3-d]pyrimidine scaffold, a library of its analogues as well as their oxidized planar counterparts were prepared utilizing a practical...

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Detalhes bibliográficos
Main Authors: Evdokimov, Nikolai M., Van slambrouck, Severine, Heffeter, Petra, Tu, Lee, Le Calvé, Benjamin, Lamoral-Theys, Delphine, Hooten, Carla J., Uglinskii, Pavel Y., Rogelj, Snezna, Kiss, Robert, Steelant, Wim F.A., Berger, Walter, Yang, Jeremy J., Bologa, Cristian G., Kornienko, Alexander, Magedov, Igor V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087497/
https://ncbi.nlm.nih.gov/pubmed/21388138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1009428
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