Novel Interactions between NFATc1 (Nuclear Factor of Activated T Cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) Mediate G Protein-coupled Receptor Agonist, Thrombin-induced Biphasic Expression of Cyclin D1, with First Phase Influencing Cell Migration and Second Phase Directing Cell Proliferation

Thrombin, a G protein-coupled receptor agonist, induced a biphasic expression of cyclin D1 in primary vascular smooth muscle cells. Although both phases of cyclin D1 expression require binding of the newly identified cooperative complex, NFATc1·STAT-3, to its promoter, the second phase, which is mor...

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Autores principales: Kundumani-Sridharan, Venkatesh, Van Quyen, Dong, Subramani, Jaganathan, Singh, Nikhlesh K., Chin, Y. Eugene, Rao, Gadiparthi N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391106/
https://ncbi.nlm.nih.gov/pubmed/22566696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.362996
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