15(S)-hydroxyeicosatetraenoic acid–induced angiogenesis requires Src-mediated Egr-1–dependent rapid induction of FGF-2 expression

To understand the mechanisms underlying 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE]–induced angiogenesis, we studied the role of Egr-1. 15(S)-HETE induced Egr-1 expression in a time-dependent manner in human dermal microvascular endothelial cells (HDMVECs). Blockade of Egr-1 via forced expressio...

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Autores principales: Kundumani-Sridharan, Venkatesh, Niu, Jixiao, Wang, Dong, Van Quyen, Dong, Zhang, Qiuhua, Singh, Nikhlesh K., Subramani, Jaganathan, Karri, Saradasri, Rao, Gadiparthi N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837334/
https://ncbi.nlm.nih.gov/pubmed/20053757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-241802
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