Protein Kinase N1 Is a Novel Substrate of NFATc1-mediated Cyclin D1-CDK6 Activity and Modulates Vascular Smooth Muscle Cell Division and Migration Leading to Inward Blood Vessel Wall Remodeling

Toward understanding the mechanisms of vascular wall remodeling, here we have studied the role of NFATc1 in MCP-1-induced human aortic smooth muscle cell (HASMC) growth and migration and injury-induced rat aortic wall remodeling. We have identified PKN1 as a novel downstream target of NFATc1-cyclin...

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Detalhes bibliográficos
Main Authors: Singh, Nikhlesh K., Kundumani-Sridharan, Venkatesh, Kumar, Sanjay, Verma, Shailendra K., Kotla, Sivareddy, Mukai, Hideyuki, Heckle, Mark R., Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476296/
https://ncbi.nlm.nih.gov/pubmed/22893700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361220
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