Protein Kinase N1 Is a Novel Substrate of NFATc1-mediated Cyclin D1-CDK6 Activity and Modulates Vascular Smooth Muscle Cell Division and Migration Leading to Inward Blood Vessel Wall Remodeling

Toward understanding the mechanisms of vascular wall remodeling, here we have studied the role of NFATc1 in MCP-1-induced human aortic smooth muscle cell (HASMC) growth and migration and injury-induced rat aortic wall remodeling. We have identified PKN1 as a novel downstream target of NFATc1-cyclin...

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Detalles Bibliográficos
Autores principales: Singh, Nikhlesh K., Kundumani-Sridharan, Venkatesh, Kumar, Sanjay, Verma, Shailendra K., Kotla, Sivareddy, Mukai, Hideyuki, Heckle, Mark R., Rao, Gadiparthi N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476296/
https://ncbi.nlm.nih.gov/pubmed/22893700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361220
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