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A Formal Synthesis of (−)-Englerin A by RRCM and Transannular Etherification

[Image: see text] A bicyclization approach to englerin A has culminated in a formal asymmetric total synthesis. Key transformations in the 10-step sequence are a regiospecific epoxide opening and a relay ene-yne-ene metathesis that converts linear substrates specifically to Δ(4,6)-guaiadiene-9,10 di...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lee, Jungyong, Parker, Kathlyn A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390928/
https://ncbi.nlm.nih.gov/pubmed/22564056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol3007524
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