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Importance of a 4-Alkyl Substituent for Activity in the Englerin Series
[Image: see text] The ring closing metathesis/transannular etherification approach to the englerin nucleus was adapted to provide two key intermediates for analogue synthesis: the 4-desmethyl Δ(5,6) tricycle and the 4-oxo Δ(5,6) tricycle. The former was elaborated to 4-desmethyl englerin A and the l...
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| Publicat a: | ACS Med Chem Lett |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2017
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512125/ https://ncbi.nlm.nih.gov/pubmed/28740610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00161 |
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