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Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole [4 + 2]/[3 + 2] cycloaddition cascade in which ele...
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| Опубликовано в: : | Chem Sci |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Royal Society of Chemistry
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5302862/ https://ncbi.nlm.nih.gov/pubmed/28194270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc04146a |
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