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Total Synthesis and Evaluation of a Key Series of C5-Substituted Vinblastine Derivatives
A remarkably concise 7–8 step total synthesis of a systematic series of key vinblastine derivatives is detailed and used to characterize the importance and probe the role of the C5 ethyl substituent (R = H, Me, Pr, CH=CH(2), C≡CH, CH(2)OH, CHO vs Et). The analogues, bearing deep-seated structural ch...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903230/ https://ncbi.nlm.nih.gov/pubmed/20518465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1027748 |
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