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Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues
Full details of the development of a direct coupling of catharanthine with vindoline to provide vinblastine are described along with key mechanistic and labeling studies. Following an Fe(III)-promoted coupling reaction initiated by generation of a presumed catharanthine radical cation that undergoes...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727944/ https://ncbi.nlm.nih.gov/pubmed/19292450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja809842b |
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