Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues

Full details of the development of a direct coupling of catharanthine with vindoline to provide vinblastine are described along with key mechanistic and labeling studies. Following an Fe(III)-promoted coupling reaction initiated by generation of a presumed catharanthine radical cation that undergoes...

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Bibliographic Details
Main Authors: Ishikawa, Hayato, Colby, David A., Seto, Shigeki, Va, Porino, Tam, Annie, Kakei, Hiroyuki, Rayl, Thomas J., Hwang, Inkyu, Boger, Dale L.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727944/
https://ncbi.nlm.nih.gov/pubmed/19292450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja809842b
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