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Total Synthesis and Evaluation of a Key Series of C5-Substituted Vinblastine Derivatives

A remarkably concise 7–8 step total synthesis of a systematic series of key vinblastine derivatives is detailed and used to characterize the importance and probe the role of the C5 ethyl substituent (R = H, Me, Pr, CH=CH(2), C≡CH, CH(2)OH, CHO vs Et). The analogues, bearing deep-seated structural ch...

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Bibliografiske detaljer
Main Authors: Va, Porino, Campbell, Erica L., Robertson, William M., Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903230/
https://ncbi.nlm.nih.gov/pubmed/20518465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1027748
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