Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20′ ethyl substituent

Por Allemann, Oliver, Cross, R. Matthew, Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Publicado no Bioorg Med Chem Lett (2017)

Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface

Por Carney, Daniel W., Lukesh, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
Publicado no Proc Natl Acad Sci U S A (2016)

Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

Por Yang, Shouliang, Sankar, Kuppusamy, Skepper, Colin K., Barker, Timothy J., Lukesh III, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
Publicado no Chem Sci (2017)

Vinblastine 20’ Amides: Synthetic Analogs That Maintain or Improve Potency and Simultaneously Overcome Pgp-derived Efflux and Resistance

Por Lukesh, John C., Carney, Daniel W., Dong, Huijun, Cross, R. Matthew, Shukla, Vyom, Duncan, Katharine K., Yang, Shouliang, Brody, Daniel M., Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Publicado no J Med Chem (2017)