Vinblastine 20’ Amides: Synthetic Analogs That Maintain or Improve Potency and Simultaneously Overcome Pgp-derived Efflux and Resistance

A series of 180 vinblastine 20’ amides were prepared in three steps from commercially available starting materials, systematically exploring a typically inaccessible site in the molecule enlisting a powerful functionalization strategy. Clear structure–activity relationships and a structural model we...

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Foilsithe in:J Med Chem
Main Authors: Lukesh, John C., Carney, Daniel W., Dong, Huijun, Cross, R. Matthew, Shukla, Vyom, Duncan, Katharine K., Yang, Shouliang, Brody, Daniel M., Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599373/
https://ncbi.nlm.nih.gov/pubmed/28857558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00958
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