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Transannular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Total Synthesis of a Unique Set of Vinblastine Analogues

[Image: see text] A powerful tandem [4+2]/[3+2] cycloaddition cascade of 1,3,4-oxadiazoles initiated by a transannular [4+2] cycloaddition is detailed. An impressive four rings, four carbon-carbon bonds, and six stereocenters are set on each site of the newly formed central six-membered ring in a ca...

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Detalhes bibliográficos
Main Authors: Campbell, Erica L., Skepper, Colin K., Sankar, Kuppusamy, Duncan, Katharine K., Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946432/
https://ncbi.nlm.nih.gov/pubmed/24087969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol402549n
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