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Versatile peptide macrocyclization with Diels-Alder cycloadditions
Macrocyclization can improve bioactive peptide ligands through preorganization of molecular topology, leading to improvement of pharmacologic properties like binding affinity, cell permeability and metabolic stability. Here we demonstrate that Diels-Alder [4+2] cycloadditions can be harnessed for pe...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7745206/ https://ncbi.nlm.nih.gov/pubmed/31523967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b07578 |
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