Versatile peptide macrocyclization with Diels-Alder cycloadditions

Macrocyclization can improve bioactive peptide ligands through preorganization of molecular topology, leading to improvement of pharmacologic properties like binding affinity, cell permeability and metabolic stability. Here we demonstrate that Diels-Alder [4+2] cycloadditions can be harnessed for pe...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Montgomery, Jeffrey E., Donnelly, Justin A., Fanning, Sean W., Speltz, Thomas E., Shangguan, Xianghang, Coukos, John S., Greene, Geoffrey L., Moellering, Raymond E.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745206/
https://ncbi.nlm.nih.gov/pubmed/31523967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b07578
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