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Versatile peptide macrocyclization with Diels-Alder cycloadditions
Macrocyclization can improve bioactive peptide ligands through preorganization of molecular topology, leading to improvement of pharmacologic properties like binding affinity, cell permeability and metabolic stability. Here we demonstrate that Diels-Alder [4+2] cycloadditions can be harnessed for pe...
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7745206/ https://ncbi.nlm.nih.gov/pubmed/31523967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b07578 |
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