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The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of previously identified, caspase-generated proapoptotic protein fragments, defined as those that increase the probability of apoptosis. In contrast...

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Bibliografski detalji
Glavni autori: Piatkov, Konstantin I., Brower, Christopher S., Varshavsky, Alexander
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390858/
https://ncbi.nlm.nih.gov/pubmed/22670058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207786109
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