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An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

INTRODUCTION: Cells synthesize glucose if deprived of it, and destroy gluconeogenic enzymes upon return to glucose-replete conditions. Gluconeogenesis (de novo synthesis of glucose) is, in effect, a reversal of glycolysis, in which glucose is converted to pyruvate. Some enzymatic steps are shared be...

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Publicat a:Science
Autors principals: Chen, Shun-Jia, Wu, Xia, Wadas, Brandon, Oh, Jang-Hyun, Varshavsky, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457285/
https://ncbi.nlm.nih.gov/pubmed/28126757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal3655
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