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Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway

Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. N-terminal sequences of AANAT enzymes vary among vertebrates. Mec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wadas, Brandon, Borjigin, Jimo, Huang, Zheping, Oh, Jang-Hyun, Hwang, Cheol-Sang, Varshavsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016120/
https://ncbi.nlm.nih.gov/pubmed/27339900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734640
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