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Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway
N(α)-terminal acetylation of cellular proteins was recently discovered to create specific degradation signals, termed Ac/N-degrons and targeted by the Ac/N-end rule pathway. We show that Hcn1, a subunit of the APC/C ubiquitin ligase, contains an Ac/N-degron that is repressed by Cut9, another APC/C s...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3665649/ https://ncbi.nlm.nih.gov/pubmed/23603116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.018 |
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