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Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

N(α)-terminal acetylation of cellular proteins was recently discovered to create specific degradation signals, termed Ac/N-degrons and targeted by the Ac/N-end rule pathway. We show that Hcn1, a subunit of the APC/C ubiquitin ligase, contains an Ac/N-degron that is repressed by Cut9, another APC/C s...

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Détails bibliographiques
Auteurs principaux: Shemorry, Anna, Hwang, Cheol-Sang, Varshavsky, Alexander
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665649/
https://ncbi.nlm.nih.gov/pubmed/23603116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.018
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