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Colon Cancer-associated DNA Polymerase β Variant Induces Genomic Instability and Cellular Transformation

Rapidly advancing technology has resulted in the generation of the genomic sequences of several human tumors. We have identified several mutations of the DNA polymerase β (pol β) gene in human colorectal cancer. We have demonstrated that the expression of the pol β G231D variant increased chromosoma...

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Bibliografski detalji
Glavni autori: Nemec, Antonia A., Donigan, Katherine A., Murphy, Drew L., Jaeger, Joachim, Sweasy, Joann B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390657/
https://ncbi.nlm.nih.gov/pubmed/22573322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.362111
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