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The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation
Approximately 30% of human tumors sequenced to date harbor mutations in the POLB gene that are not present in matched normal tissue. Many mutations give rise to enzymes that contain non-synonymous single amino acid substitutions, several of which have been found to have aberrant activity or fidelity...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624760/ https://ncbi.nlm.nih.gov/pubmed/22341651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.01.004 |
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