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The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation

Approximately 30% of human tumors sequenced to date harbor mutations in the POLB gene that are not present in matched normal tissue. Many mutations give rise to enzymes that contain non-synonymous single amino acid substitutions, several of which have been found to have aberrant activity or fidelity...

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Detalhes bibliográficos
Main Authors: Donigan, Katherine A., Hile, Suzanne E., Eckert, Kristin A., Sweasy, Joann B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624760/
https://ncbi.nlm.nih.gov/pubmed/22341651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.01.004
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