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Expression of DNA polymerase β cancer-associated variants in mouse cells results in cellular transformation
Thirty percent of the 189 tumors studied to date express DNA polymerase β variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the protein. Another variant was identified in a colon...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1242307/ https://ncbi.nlm.nih.gov/pubmed/16179390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505166102 |
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