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The I260Q Variant of DNA Polymerase Beta Extends Mispaired Primer-Termini Due To Increased Affinity for Deoxynucleotide Triphosphate Substrates
DNA polymerase beta plays a key role in base excision repair. We have previously shown that the hydrophobic hinge region of polymerase beta, which is distant from its active site, plays a critical role in the fidelity of DNA synthesis by this enzyme. The I260Q hinge variant of polymerase beta misinc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597655/ https://ncbi.nlm.nih.gov/pubmed/18937502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8011548 |
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