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The I260Q Variant of DNA Polymerase Beta Extends Mispaired Primer-Termini Due To Increased Affinity for Deoxynucleotide Triphosphate Substrates

DNA polymerase beta plays a key role in base excision repair. We have previously shown that the hydrophobic hinge region of polymerase beta, which is distant from its active site, plays a critical role in the fidelity of DNA synthesis by this enzyme. The I260Q hinge variant of polymerase beta misinc...

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Bibliografiske detaljer
Main Authors: Dala, Shibani, Starcevic, Daniela, Jaeger, Joachim, Sweasy, Joann B
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597655/
https://ncbi.nlm.nih.gov/pubmed/18937502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8011548
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