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The Asp285 Variant of DNA Polymerase Beta Extends Mispaired Primer Termini via Increased Nucleotide Binding
Endogenous DNA damage occurs at a rate of at least 20,000 lesions per cell per day. Base excision repair (BER) is a key pathway for maintaining genome stability. Several pol β variants were identified as conferring resistance to 3′-azido-3′-deoxythymidine (AZT) in E. coli.(1) Detailed biochemical st...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579761/ https://ncbi.nlm.nih.gov/pubmed/18616290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702104y |
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