The E295K DNA Polymerase Beta Gastric Cancer-Associated Variant Interferes with Base Excision Repair and Induces Cellular Transformation

Approximately 30% of human tumors examined for mutations in polymerase beta (pol β) appear to express pol β variant proteins (D. Starcevic, S. Dalal, and J. B. Sweasy, Cell Cycle 3:998-1001, 2004). Many of these variants result from a single amino acid substitution. We have previously shown that the...

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Bibliographic Details
Main Authors: Lang, Tieming, Dalal, Shibani, Chikova, Anna, DiMaio, Daniel, Sweasy, Joann B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952088/
https://ncbi.nlm.nih.gov/pubmed/17526740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01883-06
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