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The E295K DNA Polymerase Beta Gastric Cancer-Associated Variant Interferes with Base Excision Repair and Induces Cellular Transformation
Approximately 30% of human tumors examined for mutations in polymerase beta (pol β) appear to express pol β variant proteins (D. Starcevic, S. Dalal, and J. B. Sweasy, Cell Cycle 3:998-1001, 2004). Many of these variants result from a single amino acid substitution. We have previously shown that the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952088/ https://ncbi.nlm.nih.gov/pubmed/17526740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01883-06 |
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