The E288K Colon Tumor Variant of DNA Polymerase β Is a Sequence Specific Mutator

[Image: see text] DNA polymerase β (pol β) is the main polymerase involved in base excision repair (BER), which is a pathway responsible for the repair of tens of thousands of DNA lesions per cell per day. Our recent efforts in sequencing colon tumors showed that 40% of the tumors sequenced possesse...

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Huvudupphovsmän: Murphy, Drew L., Donigan, Katherine A., Jaeger, Joachim, Sweasy, Joann B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667668/
https://ncbi.nlm.nih.gov/pubmed/22650412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3003583
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