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A Viral Deubiquitylating Enzyme Restores Dislocation of Substrates from the Endoplasmic Reticulum (ER) in Semi-intact Cells

Terminally misfolded glycoproteins are ejected from the endoplasmic reticulum (ER) to the cytosol and are destroyed by the ubiquitin proteasome system. A dominant negative version of the deubiquitylating enzyme Yod1 (Yod1C160S) causes accumulation of dislocation substrates in the ER. Failure to remo...

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Main Authors: Sanyal, Sumana, Claessen, Jasper H. L., Ploegh, Hidde L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390634/
https://ncbi.nlm.nih.gov/pubmed/22619172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365312
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