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Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane

Polypeptides that fail to pass quality control in the endoplasmic reticulum (ER) are dislocated from the ER membrane to the cytosol where they are degraded by the proteasome. Derlin-1, a member of a family of proteins that bears homology to yeast Der1p, was identified as a factor that is required fo...

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Hlavní autoři: Lilley, Brendan N., Ploegh, Hidde L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242303/
https://ncbi.nlm.nih.gov/pubmed/16186509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505014102
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