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Dislocation of a Type I Membrane Protein Requires Interactions between Membrane-spanning Segments within the Lipid Bilayer

The human cytomegalovirus gene product US11 causes rapid degradation of class I major histocompatibility complex (MHCI) heavy chains by inducing their dislocation from the endoplasmic reticulum (ER) and subsequent degradation by the proteasome. This set of reactions resembles the endogenous cellular...

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Detalhes bibliográficos
Main Authors: Lilley, Brendan N., Tortorella, Domenico, Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196560/
https://ncbi.nlm.nih.gov/pubmed/12972557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-03-0192
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