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The Transmembrane Segment of a Tail-anchored Protein Determines Its Degradative Fate through Dislocation from the Endoplasmic Reticulum

Terminally misfolded proteins that accumulate in the endoplasmic reticulum (ER) are dislocated and targeted for ubiquitin-dependent destruction by the proteasome. UBC6e is a tail-anchored E2 ubiquitin-conjugating enzyme that is part of a dislocation complex nucleated by the ER-resident protein SEL1L...

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Main Authors: Claessen, Jasper H. L., Mueller, Britta, Spooner, Eric, Pivorunas, Valerie L., Ploegh, Hidde L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898349/
https://ncbi.nlm.nih.gov/pubmed/20435896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120766
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