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Screening for Natural Chemoprevention Agents that Modify Human Keap1

Upregulation of cytoprotective enzymes by therapeutic agents to prevent damage by reactive oxygen species and xenobiotic electrophiles is a strategy for cancer chemoprevention. The Kelch-like ECH-associated protein 1 (Keap1) and its binding partner, transcription factor NF-E2-related factor-2 (Nrf2)...

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Autori principali: Hu, Chenqi, Nikolic, Dejan, Eggler, Aimee L., Mesecar, Andrew D., van Breemen, Richard B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390259/
https://ncbi.nlm.nih.gov/pubmed/22074792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.10.028
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