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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

The risks of cancer and other degenerative diseases caused by reactive oxygen species and electrophiles can be reduced by the up-regulation of detoxifying enzymes. A major mechanism whereby these protective enzymes are induced occurs through activation of the antioxidant response element (ARE) by th...

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Detalhes bibliográficos
Main Authors: Eggler, Aimee L., Liu, Guowen, Pezzuto, John M., van Breemen, Richard B., Mesecar, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177374/
https://ncbi.nlm.nih.gov/pubmed/16006525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502402102
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