Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

Nitro-fatty acids (NO(2)-FAs) are electrophilic signaling mediators formed in vivo via nitric oxide (NO)- and nitrite (NO(2)(−))-dependent reactions. Nitro-fatty acids modulate signaling cascades via reversible covalent post-translational modification of nucleophilic amino acids in regulatory protei...

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Main Authors: Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077602/
https://ncbi.nlm.nih.gov/pubmed/21357422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190710
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