Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

par Padmanabhan, Balasundaram, Tong, Kit I., Kobayashi, Akira, Yamamoto, Masayuki, Yokoyama, Shigeyuki
Publié 2008

Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

par Tong, Kit I., Katoh, Yasutake, Kusunoki, Hideki, Itoh, Ken, Tanaka, Toshiyuki, Yamamoto, Masayuki
Publié 2006

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

par Tong, Kit I., Padmanabhan, Balasundaram, Kobayashi, Akira, Shang, Chengwei, Hirotsu, Yosuke, Yokoyama, Shigeyuki, Yamamoto, Masayuki
Publié 2007

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

par Ogura, Toshihiko, Tong, Kit I., Mio, Kazuhiro, Maruyama, Yuusuke, Kurokawa, Hirofumi, Sato, Chikara, Yamamoto, Masayuki
Publié 2010

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

par Kobayashi, Akira, Kang, Moon-Il, Watai, Yoriko, Tong, Kit I., Shibata, Takahiro, Uchida, Koji, Yamamoto, Masayuki
Publié 2006

Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model

par Tong, Kit I, Ota, Kazushige, Komuro, Akiyoshi, Ueda, Takeshi, Ito, Akihiko, Anne Koch, C, Okada, Hitoshi
Publié dans Cell Death Dis (2016)

The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner

par Ota, Kazushige, Tong, Kit I., Goto, Kouichiro, Tomida, Shuta, Komuro, Akiyoshi, Wang, Zhong, Nishio, Kazuto, Okada, Hitoshi
Publié dans PLoS One (2017)

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

par Shibata, Tatsuhiro, Ohta, Tsutomu, Tong, Kit I., Kokubu, Akiko, Odogawa, Reiko, Tsuta, Koji, Asamura, Hisao, Yamamoto, Masayuki, Hirohashi, Setsuo
Publié 2008

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1

par Padmanabhan, Balasundaram, Scharlock, Maria, Tong, Kit I., Nakamura, Yoshihiro, Kang, Moon-Il, Kobayashi, Akira, Matsumoto, Takehisa, Tanaka, Akiko, Yamamoto, Masayuki, Yokoyama, Shigeyuki
Publié 2004

The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

par Fujii, Shigemoto, Sawa, Tomohiro, Ihara, Hideshi, Tong, Kit I., Ida, Tomoaki, Okamoto, Tatsuya, Ahtesham, Ahmed Khandaker, Ishima, Yu, Motohashi, Hozumi, Yamamoto, Masayuki, Akaike, Takaaki
Publié 2010

Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development

par Kawazu, Masahito, Saso, Kayoko, Tong, Kit I., McQuire, Tracy, Goto, Kouichiro, Son, Dong-Ok, Wakeham, Andrew, Miyagishi, Makoto, Mak, Tak W., Okada, Hitoshi
Publié 2011

Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

par Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa
Publié 2011