Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Nrf2 is the regulator of the oxidative/electrophilic stress response. Its turnover is maintained by Keap1-mediated proteasomal degradation via a two-site substrate recognition mechanism in which two Nrf2-Keap1 binding sites form a hinge and latch. The E3 ligase adaptor Keap1 recognizes Nrf2 through...

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Main Authors: Tong, Kit I., Padmanabhan, Balasundaram, Kobayashi, Akira, Shang, Chengwei, Hirotsu, Yosuke, Yokoyama, Shigeyuki, Yamamoto, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169061/
https://ncbi.nlm.nih.gov/pubmed/17785452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00753-07
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