Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

The Keap1-Nrf2 system is central for mammalian cytoprotection against various stresses and a drug target for disease prevention and treatment. One model for the molecular mechanisms leading to Nrf2 activation is the Hinge-Latch model, where the DLGex-binding motif of Nrf2 dissociates from Keap1 as a...

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Publicado en:Commun Biol
Autores principales: Horie, Yuta, Suzuki, Takafumi, Inoue, Jin, Iso, Tatsuro, Wells, Geoffrey, Moore, Terry W., Mizushima, Tsunehiro, Dinkova-Kostova, Albena T., Kasai, Takuma, Kamei, Takashi, Koshiba, Seizo, Yamamoto, Masayuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121781/
https://ncbi.nlm.nih.gov/pubmed/33990683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02100-6
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