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Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants()

The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric Keap1 functions as the Cullin3 adaptor, and importantly, it is also the critical component of the E3 ligase that performs...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Dinkova-Kostova, Albena T., Kostov, Rumen V., Canning, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339396/
https://ncbi.nlm.nih.gov/pubmed/27497696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.08.005
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