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Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants()

The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric Keap1 functions as the Cullin3 adaptor, and importantly, it is also the critical component of the E3 ligase that performs...

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Publicat a:Arch Biochem Biophys
Autors principals: Dinkova-Kostova, Albena T., Kostov, Rumen V., Canning, Peter
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339396/
https://ncbi.nlm.nih.gov/pubmed/27497696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.08.005
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