Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells: IDENTIFICATION OF HEAT SHOCK RESPONSE AS THE MAJOR PATHWAY ACTIVATED BY NITRO-OLEIC ACID

Electrophilic fatty acid derivatives, including nitrolinoleic acid and nitro-oleic acid (OA-NO(2)), can mediate anti-inflammatory and pro-survival signaling reactions. The transcription factor Nrf2, activated by electrophilic fatty acids, suppresses redox-sensitive pro-inflammatory gene expression a...

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Autori principali: Kansanen, Emilia, Jyrkkänen, Henna-Kaisa, Volger, Oscar L., Leinonen, Hanna, Kivelä, Annukka M., Häkkinen, Sanna-Kaisa, Woodcock, Steven R., Schopfer, Francisco J., Horrevoets, Anton J., Ylä-Herttuala, Seppo, Freeman, Bruce A., Levonen, Anna-Liisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785166/
https://ncbi.nlm.nih.gov/pubmed/19808663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064873
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