Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase

Xanthine oxidoreductase (XOR) generates proinflammatory oxidants and secondary nitrating species, with inhibition of XOR proving beneficial in a variety of disorders. Electrophilic nitrated fatty acid derivatives, such as nitro-oleic acid (OA-NO(2)), display anti-inflammatory effects with pleiotropi...

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Autores principales: Kelley, Eric E., Batthyany, Carlos I., Hundley, Nicholas J., Woodcock, Steven R., Bonacci, Gustavo, Del Rio, J. Mauricio, Schopfer, Francisco J., Lancaster, Jack R., Freeman, Bruce A., Tarpey, Margaret M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606013/
https://ncbi.nlm.nih.gov/pubmed/18974051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802402200
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