Structure-Guided Design of a High-Affinity Platelet Integrin α(IIb)β(3) Receptor Antagonist That Disrupts Mg(2+) Binding to the MIDAS

An integrin found on platelets, α(IIb)β(3) mediates platelet aggregation, and α(IIb)β(3) antagonists are effective antithrombotic agents in the clinic. Ligands bind to integrins in part by coordinating a magnesium ion (Mg(2+)) located in the β subunit metal ion–dependent adhesion site (MIDAS). Drugs...

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Bibliografiske detaljer
Main Authors: Zhu, Jieqing, Choi, Won-Seok, McCoy, Joshua G., Negri, Ana, Zhu, Jianghai, Naini, Sarasija, Li, Jihong, Shen, Min, Huang, Wenwei, Bougie, Daniel, Rasmussen, Mark, Aster, Richard, Thomas, Craig J., Filizola, Marta, Springer, Timothy A., Coller, Barry S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390238/
https://ncbi.nlm.nih.gov/pubmed/22422993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003576
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