Structure-Guided Design of a High-Affinity Platelet Integrin α(IIb)β(3) Receptor Antagonist That Disrupts Mg(2+) Binding to the MIDAS

An integrin found on platelets, α(IIb)β(3) mediates platelet aggregation, and α(IIb)β(3) antagonists are effective antithrombotic agents in the clinic. Ligands bind to integrins in part by coordinating a magnesium ion (Mg(2+)) located in the β subunit metal ion–dependent adhesion site (MIDAS). Drugs...

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Detalhes bibliográficos
Main Authors: Zhu, Jieqing, Choi, Won-Seok, McCoy, Joshua G., Negri, Ana, Zhu, Jianghai, Naini, Sarasija, Li, Jihong, Shen, Min, Huang, Wenwei, Bougie, Daniel, Rasmussen, Mark, Aster, Richard, Thomas, Craig J., Filizola, Marta, Springer, Timothy A., Coller, Barry S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390238/
https://ncbi.nlm.nih.gov/pubmed/22422993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003576
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